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Related Experiment Video

Updated: Feb 27, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices

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Published on: March 21, 2025

Acute thrombus formation on phosphorilcholine surface modified flow diverters.

Miklos Marosfoi¹, Frederic Clarencon², Erin T Langan¹

¹New England Center for Stroke Research, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Journal of Neurointerventional Surgery

|July 10, 2017

Summary

Phosphorilcholine surface modified flow diverters showed significantly less thrombus formation compared to classic devices. This surface modification offers a promising approach to reduce thromboembolic complications associated with flow diverting stents.

Keywords:

dual antiplatelet therapy flow diverters intracranial aneurysms optical coherence tomography

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Published on: September 5, 2016

Area of Science:

Biomaterials Science
Medical Devices
Vascular Surgery

Background:

Thromboembolic complications are a significant limitation of current flow diverting stents.
Developing advanced stent technologies is crucial for improving patient outcomes in cerebrovascular interventions.

Purpose of the Study:

To evaluate the efficacy of phosphorilcholine surface modified flow diverters (sPED) in reducing acute thrombus formation compared to classic Pipeline Embolization Devices (cPED).
To investigate the impact of dual antiplatelet therapy (DAPT) on thrombus formation with both stent types.

Main Methods:

Elastase-induced aneurysms were created in rabbits and treated with either cPED or sPED.
Dual antiplatelet therapy (DAPT) was administered to a subset of rabbits in each group.
Intravascular optical coherence tomography (IVOCT) was used to assess thrombus formation on the flow diverters before and after angioplasty.

Main Results:

Flow diverter type significantly impacted thrombus formation (p<0.0001), while DAPT and aneurysm neck size did not.
The incidence rate of clots was 1.72 times higher with cPED compared to sPED.
Clot formation at side branch ostia was significantly lower with sPED (OR 0.180; p=0.0168).

Conclusions:

Phosphorilcholine surface modification of flow diverters is associated with reduced thrombus formation in a rabbit aneurysm model.
sPED demonstrates potential for improved safety profiles by mitigating acute thrombotic events.