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Current and future therapies for gout.

Tristan Pascart1,2, Pascal Richette3,4

  • 1a Department of Rheumatology, Lille Catholic Hospitals , University of Lille , Lomme , France.

Expert Opinion on Pharmacotherapy
|July 11, 2017
PubMed
Summary

Gout management involves treating flares and hyperuricemia. New therapies, including IL-1 inhibitors and novel uricosurics, offer improved serum uric acid reduction and better outcomes for gout patients.

Keywords:
Allopurinolanakinraarhalofenatecanakinumabcolchicinefebuxostatgoutlesinurad

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Area of Science:

  • Rheumatology
  • Pharmacology

Background:

  • Gout is a crystal-induced inflammatory arthritis caused by hyperuricemia.
  • Effective gout management requires addressing both acute flares and chronic hyperuricemia.
  • Recent advancements have led to new therapeutic options for gout.

Purpose of the Study:

  • To review current and emerging treatments for gout flares and hyperuricemia.
  • To discuss the optimal use of established gout medications.
  • To highlight the potential of novel pharmacotherapies.

Main Methods:

  • Literature review of existing and emerging gout treatments.
  • Analysis of clinical evidence for approved and investigational drugs.
  • Synthesis of expert opinion on current treatment paradigms.

Main Results:

  • Colchicine, NSAIDs, and corticosteroids remain key for flare management.
  • Interleukin-1 inhibitors show promise for refractory gout flares.
  • Febuxostat and newer uricosurics (lesinurad, arhalofenate) offer enhanced serum uric acid reduction, often in combination therapy.

Conclusions:

  • Optimal use of established gout therapies is crucial.
  • Novel agents, including IL-1 inhibitors and combination therapies, expand treatment options.
  • Emerging treatments hold promise for achieving target serum uric acid levels in more patients.