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Correlation between serum ferritin and bone marrow iron stores.

Anupama K V1, Purnima S Rao2, Sushma Adappa3

  • 11 Resident, Department of Medicine, Kasturba Medical College, Manipal University, Mangalore, India.

Tropical Doctor
|July 11, 2017
PubMed
Summary

This study establishes a serum ferritin cutoff of 228 pmol/L to accurately predict bone marrow iron deficiency. This finding aids in diagnosing iron status non-invasively.

Keywords:
Bone marrowGale’s methodanaemiairon deficiencyserum ferritin

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Diagnostic Medicine

Background:

  • Bone marrow iron stores are crucial indicators of iron status.
  • Accurate assessment of bone marrow iron is essential for diagnosing and managing iron-related disorders.
  • The correlation between serum ferritin and bone marrow iron stores requires further clarification due to undefined cutoff values.

Purpose of the Study:

  • To investigate the detailed correlation between serum ferritin levels and bone marrow iron stores.
  • To establish a reliable cutoff value for serum ferritin to predict bone marrow iron deficiency.

Main Methods:

  • A cross-sectional study design was employed.
  • Bone marrow samples were stained using Perl's Prussian blue and assessed with Gale's grading.
  • Statistical analyses included Receiver Operating Characteristic (ROC) curve analysis and Spearman's correlation coefficient.

Main Results:

  • Gale's grading identified iron store deficiency in 26 participants and sufficiency in 13.
  • A strong positive correlation (Spearman's coefficient = 0.90) was observed between serum ferritin and bone marrow iron stores.
  • A serum ferritin level of 228 pmol/L demonstrated high sensitivity and specificity for predicting iron deficiency.

Conclusions:

  • Serum ferritin is a reliable indicator of bone marrow iron stores.
  • A serum ferritin cutoff of 228 pmol/L is proposed for predicting bone marrow iron deficiency.
  • This cutoff value can aid in non-invasive assessment of iron status.