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Hepatitis C Infection: A Systemic Disease

Zobair M Younossi1

  • 1Betty and Guy Beatty Center for Integrated Research, Inova Health System, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA.

Clinics in Liver Disease
|July 11, 2017
PubMed

Insights

Hepatitis C virus (HCV) infection causes systemic disease with liver and other complications. A comprehensive view of HCV

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection is often viewed primarily as a liver disease.
  • However, HCV infection presents significant extrahepatic manifestations and systemic complications.
  • The full impact of HCV is not solely defined by clinical outcomes.

Purpose of the Study:

  • To emphasize the systemic nature of hepatitis C virus (HCV) infection.
  • To advocate for a comprehensive assessment of HCV's burden, including clinical, economic, and patient-reported outcomes.
  • To highlight the societal and individual benefits of curing HCV.

Main Methods:

  • Literature review and synthesis of existing data on HCV's clinical manifestations.
  • Analysis of economic impact studies related to HCV.
  • Review of patient-reported outcome measures in HCV-infected populations.

Main Results:

  • HCV infection is a systemic disease with diverse hepatic and extrahepatic complications.
  • The economic burden of HCV includes direct medical costs and indirect costs like lost productivity.
  • Patient-reported outcomes reveal significant impacts on quality of life.

Conclusions:

  • A holistic understanding of HCV requires integrating clinical, economic, and patient-centered perspectives.
  • Recognizing the multifaceted burden of HCV is essential for appreciating the value of curative therapies.
  • Curing HCV offers substantial benefits to both individual patients and society.

Keywords:
Extrahepatic complicationsHepatic complicationsHepatitis C virus

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