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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Feb 27, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
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Published on: August 1, 2014

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Cell therapy and vocal fold scarring.

A Mattei1, J Magalon2, B Bertrand3

  • 1Aix Marseille université, 13000 Marseille, France; Service d'oto-rhino-laryngologie et chirurgie cervicofaciale, La Conception, Assistance publique-Hôpitaux de Marseille, 147, boulevard Baille, 13005 Marseille, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|July 11, 2017
PubMed
Summary

Cell therapy, particularly using mesenchymal stem cells from adipose tissue, shows promise for treating vocal fold scarring and improving voice disorders. The stromal vascular fraction may enhance therapeutic outcomes.

Keywords:
Adipose-derived stem cellsFibrosisMesenchymal stem cellsScarVocal fold

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Nerve Stimulator-guided Injection of Autologous Stem Cells Near the Equine Left Recurrent Laryngeal Nerve
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Area of Science:

  • Regenerative Medicine
  • Otolaryngology
  • Biomaterials Science

Background:

  • Laryngeal microsurgery can cause vocal fold scarring, impairing vibration and leading to dysphonia.
  • Current treatments for vocal fold scarring are limited and often ineffective for restoring vibration.
  • Adipose-derived stromal vascular fraction (SVF) is being explored as a potential therapeutic agent.

Purpose of the Study:

  • To review the current literature on cell therapy for vocal fold scarring.
  • To analyze the therapeutic potential of adipose-derived SVF for vocal fold scarring.

Main Methods:

  • A PubMed search identified 27 articles (2003-2016) on stem cells for vocal fold scarring.
  • Studies included in vitro (fibroblasts) and in vivo (animal) models.
  • Evaluated scar morphology, viscoelastic properties, extracellular matrix, fibroblast behavior, and stem cell survival/differentiation.

Main Results:

  • Mesenchymal stem cells (MSCs), especially those from adipose tissue, demonstrated benefits in treating vocal fold scarring.
  • Adipose-derived MSCs showed particular promise in improving scar characteristics.
  • SVF exhibited properties that could streamline production and potentially improve therapeutic results.

Conclusions:

  • Mesenchymal stem cell therapy, particularly with adipose-derived cells, is a promising avenue for treating vocal fold scarring.
  • Adipose-derived SVF holds significant therapeutic interest due to its potential benefits and logistical advantages.
  • Further research into adipose-derived SVF could lead to improved treatments for disabling dysphonia caused by vocal fold scarring.