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Related Experiment Video

Updated: Feb 27, 2026

Intraductal Delivery and X-ray Visualization of Ethanol-Based Ablative Solution for Prevention and Local Treatment of Breast Cancer in Mouse Models
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Preventing invasive breast cancer using endocrine therapy.

Mangesh A Thorat1, Jack Cuzick1

  • 1Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.

Breast (Edinburgh, Scotland)
|July 11, 2017
PubMed
Summary

Preventive therapies like selective oestrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) significantly reduce breast cancer incidence, particularly for ER-positive cases. Discussing these options with high-risk women is crucial for effective breast cancer prevention.

Keywords:
Aromatase inhibitorsBreast cancerBreast cancer riskPreventionSERMsTamoxifen

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Area of Science:

  • Oncology
  • Preventive Medicine
  • Pharmacology

Background:

  • Breast cancer mortality has decreased in developed nations due to improved treatments.
  • However, breast cancer incidence is rising, necessitating enhanced preventive strategies.
  • Therapeutic agents offer a promising avenue for controlling the increasing breast cancer burden.

Purpose of the Study:

  • To evaluate the efficacy of selective oestrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) in breast cancer prevention.
  • To assess the impact of these agents on estrogen receptor-positive (ER+) breast cancers.
  • To inform clinical guidelines regarding preventive therapy for high-risk women.

Main Methods:

  • Analysis of high-quality evidence from 9 major trials (over 83,000 participants) for SERMs.
  • Combined results from 2 large trials (8,424 participants) for AIs.
  • Review of long-term follow-up data, including the IBIS-I trial.

Main Results:

  • SERMs demonstrated a 38% reduction in breast cancer incidence.
  • Aromatase inhibitors showed a 53% reduction in breast cancer incidence.
  • Benefits were exclusively observed in the prevention of ER-positive breast cancers.

Conclusions:

  • Preventive therapies, particularly SERMs and AIs, are effective in reducing breast cancer incidence, especially in ER-positive cases.
  • Targeting high-risk women with preventive therapy improves the benefit-harm ratio.
  • Enhanced risk-prediction models, biomarkers, and increased awareness among healthcare professionals and patients are essential for optimal utilization of preventive strategies.