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Federating Heterogeneous Datasets to Enhance Data Sharing and Experiment Reproducibility.

Juan C Prieto¹, Beatriz Paniagua¹, Marilia S Yatabe²

¹NIRAL, UNC, Chapel Hill, North Carolina, United States.

Proceedings of Spie--The International Society for Optical Engineering

|July 11, 2017

Summary

Reproducibility in scientific research is challenging. Shiny-tooth, a web application, enhances clinical trial data acquisition and sharing to improve experiment reproducibility, currently used for an osteoarthritis study.

Keywords:

Data federation clinical data de-identified reproducibility sharing web visualization

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Area of Science:

Biomedical Imaging
Clinical Data Management
Scientific Reproducibility

Background:

Replication of scientific findings is increasingly difficult, with smaller effect sizes reported in subsequent studies.
Complex experimental designs and pressure for positive results contribute to reproducibility issues.
The International Committee of Medical Journal Editors recommends data sharing plans to enhance transparency.

Purpose of the Study:

To introduce Shiny-tooth, a web-based application designed to improve clinical data acquisition.
To facilitate data federation of clinical and morphological data from medical images.
To address the growing demand for enhanced data management and sharing for future experiment reproducibility.

Main Methods:

Development of Shiny-tooth, a web-based application for clinical trial data management.
Implementation of data federation capabilities for clinical and image-derived morphological data.
Current application of Shiny-tooth for storing clinical data from an osteoarthritis study.

Main Results:

Shiny-tooth improves clinical data acquisition during trials.
The application enables data federation across different data types.
It provides a centralized system for managing study data, exemplified by its use in an OA study.

Conclusions:

Shiny-tooth offers a solution to enhance clinical data management and sharing.
The application supports the goal of improving scientific experiment reproducibility.
Its current use in an osteoarthritis study demonstrates its practical utility.