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New Direct-Acting Antiviral Agents and Immunomodulators for Hepatitis B Virus Infection

Marion G Peters1, Stephen Locarnini1

  • 1Dr Peters is a professor of medicine and chief of hepatology research in the Department of Medicine at the University of California in San Francisco, California. Dr Locarnini is a professor of microbiology and immunology at the University of Melbourne and is director of the WHO Regional Reference Laboratory for Hepatitis B within the Victorian Infectious Diseases Reference Laboratory at the Doherty Institute in Melbourne, Australia.

Gastroenterology & Hepatology
|July 11, 2017
PubMed

Insights

New treatments for chronic hepatitis B (CHB) are in development, targeting the hepatitis B virus (HBV) life cycle and immune response. Understanding CHB phases and HBV life cycle is key for effective new therapy combinations.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Chronic hepatitis B (CHB) impacts over 350 million globally, being a leading cause of liver cancer.
  • Current CHB therapies manage the condition but do not offer a cure.
  • CHB affects 2-3 million in the U.S. alone.

Purpose of the Study:

  • To review the various phases of CHB and the hepatitis B virus (HBV) life cycle.
  • To discuss the mechanisms of action for novel CHB therapeutic molecules.
  • To explore potential combination strategies for new CHB therapies across different disease phases.

Main Methods:

  • Review of preclinical and phase 2 studies for over 30 new molecules targeting HBV.
  • Analysis of HBV life cycle and host immune response pathways.
  • Examination of therapeutic strategies for CHB management.

Main Results:

  • Over 30 novel molecules are under investigation, targeting distinct aspects of HBV replication and host immunity.
  • Understanding of HBV lifecycle and CHB disease progression is crucial for therapeutic development.
  • Potential for combination therapies exists to improve CHB treatment outcomes.

Conclusions:

  • Novel therapeutic approaches for CHB are emerging, focusing on specific viral and host targets.
  • A comprehensive understanding of CHB phases and HBV biology is essential for advancing treatment.
  • Future CHB treatment may involve combination therapies tailored to disease stage.
Keywords:
HBV life cycleHBsAg release inhibitorsRNA silencingTLR agonistscapsid inhibitorscheckpoint inhibitorstherapeutic vaccines

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