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Related Experiment Video

Updated: Feb 27, 2026

Murine Model of CD40-activation of B cells

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

What Else Can CD39 Tell Us?

Hai Zhao¹, Cong Bo¹, Yan Kang¹

¹Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Immunology

|July 11, 2017

Summary

This summary is machine-generated.

CD39 (ectonucleoside triphosphate diphosphohydrolase 1) is a key enzyme in immune suppression. Targeting CD39 offers potential for novel cancer immunotherapies and as a marker for regulatory T cells (Tregs).

Keywords:

Bregs CD161 CD39 Th17 cell Tregs adenosine extracellular ATP γδ T cell

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Last Updated: Feb 27, 2026

Murine Model of CD40-activation of B cells

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Published on: March 5, 2010

A Method For Production of Recombinant mCD1d Protein in Insect Cells.

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Published on: June 2, 2021

Area of Science:

Immunology
Biochemistry
Oncology

Background:

CD39 is the rate-limiting enzyme in the ATP/ADP-AMP-adenosine pathway.
Adenosine signaling plays a critical role in immune suppression within the tumor microenvironment.

Purpose of the Study:

To review current research on the CD39 ectoenzyme.
To explore the clinical applications of CD39 as a therapeutic target and biomarker.

Main Methods:

Literature review of studies investigating CD39's enzymatic function.
Analysis of CD39's role in immune cell populations (Tregs, Th17, Vγ9Vδ2 T cells).
Examination of CD39's impact on tumor immunosuppression.

Main Results:

CD39 inhibition can alleviate tumor-associated immunosuppression.
CD39high Tregs exhibit sustained function and Foxp3 levels, suggesting potential as a Treg marker.
CD39 dephosphorylates phosphoantigens, impacting Vγ9Vδ2 T cell activity, a promising target for cellular vaccines.
CD39 is associated with Th17 cells and may serve as a marker for them.

Conclusions:

CD39 represents a promising target for checkpoint inhibition to counteract adenosine-mediated immune suppression.
CD39's distinct expression and function in Tregs highlight its potential as a specific biomarker.
Targeting CD39 offers therapeutic avenues in cancer immunotherapy and cellular vaccine development.