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Human ivermectin exposure.

A H Hall, D G Spoerke, A C Bronstein

    The Journal of Emergency Medicine
    |January 1, 1985
    PubMed
    Summary
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    Veterinary ivermectin (antiparasitic drug) exposure in humans can cause adverse effects, including nausea and pain, following accidental injection. Ingestion may lead to asymptomatic outcomes, but increased veterinary use anticipates more human exposures.

    Area of Science:

    • Veterinary pharmacology
    • Toxicology
    • Human medicine

    Background:

    • Ivermectin is a widely used antiparasitic medication in veterinary practice for domestic animals.
    • The increasing frequency of ivermectin use in animals raises concerns about potential human exposure.
    • Understanding the toxicological profile of veterinary ivermectin in humans is crucial.

    Observation:

    • Two distinct cases of human exposure to veterinary ivermectin preparations are documented.
    • Case 1 involved accidental self-injection, leading to symptoms like nausea, pallor, and localized pain/numbness.
    • Case 2 involved a child ingesting an unknown amount of ivermectin paste, resulting in no apparent symptoms.

    Findings:

    • Accidental self-injection of veterinary ivermectin can result in transient adverse health effects in humans.

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  • Ingestion of veterinary ivermectin, even in significant amounts, may not always cause symptomatic illness in children.
  • Human responses to veterinary ivermectin exposure can vary significantly based on the route and amount of exposure.

    • Implications:

    • Healthcare providers should be aware of potential ivermectin exposure from veterinary sources, especially with increasing animal use.
    • Accurate reporting and investigation of human exposures are essential for public health surveillance.
    • Further research into the safety and toxicokinetics of veterinary ivermectin formulations in humans is warranted.