Related Experiment Video
Updated: Aug 18, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016
Dose versus survival time curves in the evaluation of 'prompt' and 'delayed' acute toxicities
Abstract:
The acute toxicity of arecoline, diisopropylfluorophosphate, nicotine and pilocarpine alone or in association with atropine has been evaluated from percentage lethality and from the linear correlation of (doses/(survival time] vs doses. The experimental points obtained with arecoline and diisopropylfluorophosphate, alone or in association with atropine 50 mg kg-1, are apparently ordered according to two straight lines. That at lower doses gave the LD50 values of the compounds studied. The values found are comparable to those found with percentage lethality. The straight line found at high doses may indicate that over certain doses the drugs kill by a different mechanism. It is concluded that the evaluation of the survival time may be a reliable method in identifying and in evaluating quantitatively the two forms of toxicity.
Related Concept Videos
Dose-Response Relationship: Overview
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
Dose Response Curve: Conventional Versus Nonmonotonic
Toxicity Testing in Animals

