Relationships between obsessive-compulsive disorder, depression and functioning before and after exposure and
Sarosh J Motivala1, Maria Arellano2, Rebecca L Greco2
1a Department of Psychiatry , University of California Los Angeles , Los Angeles , CA , USA.
International Journal of Psychiatry in Clinical Practice
|July 11, 2017
Summary
Exposure and response prevention (ERP) therapy improved obsessive-compulsive disorder (OCD) symptoms, depression, and functioning. Post-treatment, functioning and depression became more strongly linked, with rumination also mediating symptom-depression relationships.
Area of Science:
- Psychiatry and Behavioral Science
- Clinical Psychology
Background:
- Obsessive-compulsive disorder (OCD) is frequently comorbid with depression and significantly impairs daily functioning.
- Exposure and response prevention (ERP) is a primary cognitive-behavioral therapy for OCD, but its impact on mediating factors requires further investigation.
Purpose of the Study:
- To investigate the mediation roles of functioning, depression, rumination, and worry in the relationship between OCD symptoms and functioning before and after ERP treatment.
- To understand how these cognitive and functional factors change and interact following intensive ERP therapy.
Main Methods:
- A randomized controlled trial involving 44 individuals with OCD, allocated to immediate ERP or a waitlist control group.
- Bootstrapping methods were employed to analyze mediation models, assessing the relationships between OCD symptoms, depression, functioning, rumination, and worry pre- and post-intervention.
Main Results:
- Significant improvements in OCD symptoms, depression, and functioning were observed post-ERP treatment.
- Functioning was found to mediate the link between OCD symptoms and depression. The association between functioning and depression strengthened post-treatment.
- Depression and rumination emerged as significant mediators between OCD symptoms and functioning, particularly at the post-treatment stage.
Conclusions:
- ERP treatment enhances the interconnectedness of depression and functioning in individuals with OCD.
- Post-ERP, interventions targeting depression (e.g., medication, cognitive therapy) and enhancing functioning (e.g., behavioral activation) are crucial for comprehensive OCD patient care.
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