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Sepsis-related mortality in the Czech Republic: multiple causes of death analysis
Insights
Sepsis-related deaths in the Czech Republic nearly tripled from 1998-2011, primarily affecting individuals over 65. This rise highlights the growing burden of sepsis due to an aging population and chronic diseases.
Area of Science:
- Public Health
- Epidemiology
- Gerontology
Background:
- Sepsis is a frequent, life-threatening complication in hospitalized patients.
- Nationwide analysis of sepsis-related mortality in the Czech Republic was lacking.
- Population aging and chronic diseases contribute to increased sepsis risk.
Purpose of the Study:
- To analyze trends and disparities in sepsis-related mortality in the Czech Republic (1998-2011).
- To utilize multiple cause of death data for a comprehensive analysis.
Main Methods:
- Analysis of individual death records from the Institute for Health Information and Statistics.
- Identification of sepsis-related deaths using ICD-10 codes.
- Calculation of frequencies, age-standardized rates, and comorbidity patterns.
Main Results:
- Sepsis was associated with 41,425 deaths (3%) between 1998-2011.
- Sepsis-related mortality nearly tripled, with the largest increase in those aged 65 and over.
- Sepsis was the immediate cause of death in 66% of cases, indicating underestimation in underlying cause statistics.
Conclusions:
- Sepsis mortality is increasing, driven by population aging and chronic disease complications.
- Upward trends suggest continued increases in sepsis-related mortality.
- Preventive strategies in clinical sepsis management are recommended.
Aim:
Sepsis represents an increasingly frequent complication in the survival of the hospitalized persons. The nation-wide burden of the sepsis-related mortality in the Czech Republic has not yet been analysed. The present study aims to assess the trends and the disparities in the sepsis-related mortality in the Czech Republic for the period 1998-2011 using multiple causes of death reported on the death certificates.
Materials And Methods:
Individual death records provided by the Institute for Health Information and Statistics were used to identify sepsis-related deaths based on the codes of the 10th revision of the International classification of the diseases (ICD-10). Frequencies, age-standardized rates and comorbidity patterns were studied.
Results:
A total of 41,425 cases (3%) out of 1,456,539 deaths within the period 1998-2011 were associated with sepsis. In 2011, sepsis was reported in 8% of all in-hospital deaths. Sepsis is the most likely to be reported as immediate cause of death (66%), which results in its considerable underestimation in the underlying cause of death statistics. The sepsis-related mortality almost tripled between 1998 and 2011, and the most of the increase is attributable to persons aged 65 and over. In 44% of cases, circulatory disease or cancer was reported as the underlying cause of death. Significant associations with sepsis were however found for infectious diseases, diseases of skin, and metabolic or musculoskeletal disorders.
Conclusion:
Multiple cause of death analysis of sepsis-related mortality revealed that sepsis represents a growing burden related to the population ageing and increased prevalence of complications of chronic diseases. The observed upward trends, as well as the expected continuation of the ageing process, may result in further increase of sepsis-related mortality. Preventive measures in the clinical management of sepsis are recommended.
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