Related Experiment Video
Updated: Aug 12, 2026

07:32
Novel Apparatus and Method for Drug Reinforcement
Published on: August 20, 2010
Epidemic free-base cocaine abuse. Case study from the Bahamas
Lancet (London, England)
|March 1, 1986
Summary
A surge in cocaine abuse admissions in the Bahamas was linked to a shift from cocaine hydrochloride to highly addictive cocaine free base. This change triggered a significant public health crisis, marking the first reported nationwide epidemic primarily from free base cocaine.
Area of Science:
- Public Health
- Addiction Medicine
- Epidemiology
Background:
- A notable increase in new admissions for cocaine abuse was observed in the Bahamas starting in 1983.
- This rise affected both the sole psychiatric hospital and the main outpatient psychiatric clinic.
Purpose of the Study:
- To investigate the causes behind the sharp increase in cocaine abuse admissions in the Bahamas.
- To identify the specific form of cocaine driving this public health crisis.
Main Methods:
- Analysis of admission data from psychiatric facilities in the Bahamas between 1982 and 1984.
- Correlation of admission trends with changes in cocaine availability and form.
Main Results:
- New admissions for cocaine abuse rose from zero in 1982 to 69 in 1983 and 523 in 1984.
- A primary driver identified was the switch by drug pushers to selling cocaine free base, known for its high addictive potential, over cocaine hydrochloride.
Conclusions:
- The findings indicate a public health epidemic in the Bahamas primarily caused by the widespread use of cocaine free base.
- This is the first reported nationwide medical epidemic attributed almost exclusively to cocaine free base, despite rising global use.
Related Concept Videos
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drug Abuse and Addiction: Pharmacological Phenomena
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
Stimulants
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

