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Updated: Feb 27, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery
Jamie C Gaitor1, Lauren M Paul, Melissa M Reardon
1Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, Florida 33965, USA. amirjafari@fgcu.edu.
Abstract:
This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

