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Clinicians value the Response Evaluation Criteria in Solid Tumors (RECIST) for trial objectivity but note limitations. The criteria may not always reflect true clinical benefit, highlighting a disconnect between radiological assessment and patient outcomes.

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Area of Science:

  • Oncology
  • Clinical Trials
  • Radiology

Background:

  • The Response Evaluation Criteria in Solid Tumors (RECIST) were developed to standardize radiological assessment in cancer clinical trials.
  • There is uncertainty regarding whether RECIST's defined percentage changes in tumor size reflect true clinical benefit.

Purpose of the Study:

  • To investigate clinicians' opinions and experiences with RECIST in current oncology practice.
  • To assess the perceived value and limitations of RECIST in gynecologic cancer trials.

Main Methods:

  • A web-based questionnaire survey was distributed to medical professionals at a comprehensive cancer center and international gynecologic cancer specialists.
  • Sixty medical professionals from 13 countries responded, focusing on attitudes towards RECIST use.

Main Results:

  • 66% of respondents felt RECIST improved trial objectivity and response assessment.
  • 60% observed patients discontinuing trials due to clinical rather than radiological progression.
  • Both target and non-target progression were considered equally important for clinical decision-making.

Conclusions:

  • RECIST is recognized as valuable for clinical trial endpoint assessment, but practical limitations exist.
  • A disconnect between radiological findings and the clinical picture necessitates improved metrics for patient benefit.
  • Continued efforts are needed to enhance assessment of patient benefit in clinical trials.