Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Circulating Tumor Cells: From Basic to Translational Research.

Clinical chemistry·2024

Same author

EpCAM-positive circulating tumor cells and serum AFP levels predict outcome after curative resection of hepatocellular carcinoma.

Scientific reports·2023

Same author

Protocol of the IntenSify-Trial: An open-label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab-paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy.

Clinical and translational science·2023

Same author

RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.

Cell death & disease·2023

Same author

[Liquid Biopsy - A new diagnostic concept in oncology].

Laryngo- rhino- otologie·2023

Same author

Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients.

International journal of molecular sciences·2023

Same journal

Efficacy of Honey Combined with Cryotherapy in the Prevention and Management of Radiation-Induced Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Head and Neck Cancer.

Oncology research and treatment·2026

Same journal

Three therapeutic modalities for advanced ovarian cancer: real world data from a certified oncological center.

Oncology research and treatment·2026

Same journal

Real world experiences in the treatment of immune thrombocytopenia over a two-year period.

Oncology research and treatment·2026

Same journal

Safety and preliminary activity of neoadjuvant trastuzumab deruxtecan (T-DXd) plus 5-fluorouracil and folinic acid for HER2-positive, resectable esophagogastric adenocarcinoma: Results from the safety run-in cohort of the phase Ib/II UCCL-AIO-STO0124-IKF072 NeoART trial.

Oncology research and treatment·2026

Same journal

Genitourinary Oncology Highlights from the European Society for Medical Oncology Annual Meeting 2025: Advances in Renal Cell Carcinoma and Muscle-invasive Bladder Cancer.

Oncology research and treatment·2026

Same journal

The Role of Regulatory Policies in Shaping Outpatient Cancer Treatment in Germany: A Comparative Perspective.

Oncology research and treatment·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Liquid Biopsy: Current Status and Future Perspectives.

Sonja Mader, Klaus Pantel

Oncology Research and Treatment

|July 11, 2017

Summary

This summary is machine-generated.

Liquid biopsies offer a less invasive way to track cancer's molecular evolution. Analyzing blood can reveal tumor changes and guide personalized cancer therapies, overcoming limitations of primary tumor analysis.

Keywords:

Circulating tumor cell (CTC)Exosomes Liquid biopsy cfRNA ctDNA

More Related Videos

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Feb 27, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

Area of Science:

Oncology
Molecular Biology
Genomics

Background:

Cancer therapies are often based on primary tumor molecular traits, which can change in metastases.
Metastatic evolution is a major cause of cancer mortality, necessitating dynamic monitoring.
Primary tumor analysis and invasive metastatic biopsies have limitations in capturing tumor heterogeneity.

Purpose of the Study:

To introduce various blood-based liquid biopsy approaches.
To discuss the clinical applications of liquid biopsies in oncology.
To highlight how liquid biopsies can overcome limitations of traditional tissue biopsies.

Main Methods:

Review of different liquid biopsy techniques.
Analysis of circulating tumor cells (CTCs).
Detection of tumor-derived cell-free nucleic acids, exosomes, and platelets in blood.

Main Results:

Liquid biopsies can reflect the molecular profile of multiple tumor subclones.
Sequential monitoring of disease evolution is feasible through serial liquid biopsies.
Potential to improve patient stratification and therapeutic selection.

Conclusions:

Liquid biopsies provide a comprehensive and dynamic view of cancer's molecular landscape.
These non-invasive methods offer significant advantages over traditional tissue biopsies.
Liquid biopsies hold great promise for advancing personalized oncology and improving patient outcomes.