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Updated: Feb 26, 2026

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
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Transparent Silk Fibroin Microspheres from Controlled Droplet Dissolution in a Binary Solution.

Fernando Jativa1,2, Xuehua Zhang2,3

  • 1Department of Biomedical Engineering, University of Melbourne , Parkville, Victoria 3010, Australia.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 12, 2017
PubMed
Summary

Researchers developed a simple droplet dissolution method to create wrinkled silk fibroin microspheres. These silk spheres exhibit tunable transparency and potential applications in optics and drug delivery.

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Area of Science:

  • Materials Science
  • Polymer Science
  • Biomaterials Engineering

Background:

  • Silk fibroin, a natural polymer, has diverse applications but requires controlled morphology for structured materials.
  • Fabricating silk-based materials necessitates precise control over silk fibroin assembly and structure.

Purpose of the Study:

  • To develop an effective and simple method for fabricating silk fibroin microspheres with controlled microstructures.
  • To investigate the droplet dissolution process for tailoring the surface morphology and properties of silk assemblies.

Main Methods:

  • A sessile microdrop of silk fibroin solution was immersed in a surrounding phase of ethanol in toluene.
  • The droplet underwent a two-phase process: solvent intake causing expansion, followed by droplet dissolution.
  • Microstructure formation was controlled by adjusting the composition of the surrounding solution, particularly ethanol concentration.

Main Results:

  • Silk fibroin microspheres with diameters of several hundred micrometers were successfully produced.
  • The microspheres exhibited regular wrinkled microstructures on their surface due to shell wrinkling during dissolution.
  • The resulting silk spheres showed switchable transparency for visible light.

Conclusions:

  • Controlled droplet dissolution is a novel and effective strategy for tailoring silk assembly microstructures.
  • The developed method offers a simple approach to create silk microspheres with tunable surface features.
  • These silk microspheres show potential for use as optical units or microcarriers in various applications.