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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Feb 26, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Patient and Provider Characteristics Associated With Optimal Post-Fracture Osteoporosis Management.

Natalie N Boytsov1, Albert G Crawford2, Leslie Ann Hazel-Fernandez3

  • 11 Eli Lilly and Company, Indianapolis, IN.

American Journal of Medical Quality : the Official Journal of the American College of Medical Quality
|July 12, 2017
PubMed
Summary

Optimal osteoporosis management after fractures is low. This study found patient demographics and location impact care quality, highlighting needs for targeted interventions to improve osteoporosis outcomes.

Keywords:
HEDISfractureosteoporosisosteoporosis therapy

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Area of Science:

  • Geriatric Medicine
  • Public Health
  • Health Services Research

Background:

  • Osteoporosis (OP) causes millions of fractures yearly, yet post-fracture management quality is suboptimal.
  • Current quality measures, like HEDIS, aim to standardize optimal OP care.
  • Identifying factors influencing care quality is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine patient and provider characteristics linked to achieving optimal post-fracture OP management.
  • To analyze disparities in OP care quality among older women.
  • To inform strategies for enhancing post-fracture OP care.

Main Methods:

  • Retrospective cohort study of women aged 67-85 with at least one fracture.
  • Analysis of enrollment data from a major health insurance plan (Humana).
  • Comparison of demographic and geographic factors between patients achieving and not achieving optimal OP management.

Main Results:

  • Significant differences in OP care achievement were observed across racial groups (Black women more in the 'not achieved' group; Hispanic women more in the 'achieved' group).
  • Patients in the 'not achieved' group were more likely to reside in the South and in urban/suburban areas.
  • A majority of primary care and OP-specialty providers did not meet the 4-star OP quality rating.

Conclusions:

  • Patient race/ethnicity and geographic location are associated with variations in post-fracture osteoporosis management.
  • Provider performance also impacts the achievement of quality care standards.
  • Findings support developing predictive models to identify at-risk women for targeted interventions to improve osteoporosis care.