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Published on: March 12, 2018
Clinical manifestations and diagnostic methods in pulmonary angiosarcoma: protocol for a scoping review
Rachel Lim1, Lea Harper2, John Swiston3
1Cumming School of Medicine, University of Calgary, Foothills Medical Centre, Room 933, North Tower, 1403-29 Street NW, Calgary, AB, T2N 2T9, Canada. Rachel.Lim@albertahealthservices.ca.
Background:
Angiosarcoma involving the lung can represent either primary or metastatic malignancy. Due to the rarity of this condition, knowledge surrounding the natural history and clinical presentation is scarce. The aim of this scoping review is to summarize the existing literature on pulmonary angiosarcoma, particularly as it pertains to the clinical presentation and ancillary tests used for diagnosis in addition to histopathology.
Methods:
We will conduct a systematic search using Ovid MEDLINE and EMBASE electronic databases. Two investigators will independently screen identified titles and abstracts to select articles reporting on pulmonary angiosarcoma. The data will be summarized in a narrative fashion and organized according to aspects of epidemiology, risk factors, clinical presentation, diagnostic methods, and treatment.
Discussion:
Scoping reviews are increasingly used to synthesize the evidence on a particular topic, to identify gaps in the literature, and to determine if future systematic reviews are feasible. In order to improve the care of patients with angiosarcoma, earlier recognition and diagnosis is required. This review will be valuable for highlighting the range of clinical presentations and the role of imaging and other diagnostic tools in the diagnosis of metastatic and primary pulmonary angiosarcoma.
Systematic Review Registration:
PROSPERO registration: CRD42017059052.
