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Piperacillin: in vitro evaluation.

G P Bodey, B Le Blanc

    Antimicrobial Agents and Chemotherapy
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Piperacillin, a new penicillin antibiotic, shows potent in vitro activity against various gram-negative bacilli, including Pseudomonas aeruginosa and Escherichia coli. Its efficacy varies with bacterial inoculum size, media type, and pH, but it is more active than carbenicillin and ticarcillin.

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    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Antibiotic resistance is a growing concern in treating bacterial infections.
    • Semisynthetic penicillins offer potential solutions for combating resistant pathogens.
    • Piperacillin represents a novel semisynthetic penicillin with potential clinical applications.

    Purpose of the Study:

    • To evaluate the in vitro antimicrobial activity of piperacillin against a range of clinical isolates.
    • To compare the efficacy of piperacillin with other established penicillins.

    Main Methods:

    • In vitro susceptibility testing was performed on 577 clinical isolates.
    • Testing included gram-positive cocci and gram-negative bacilli.
    • Minimum inhibitory concentrations (MICs) were determined for piperacillin.

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    Main Results:

    • Piperacillin demonstrated significant activity against Pseudomonas aeruginosa (92%), Serratia marcescens (82%), and Escherichia coli (73%) at 12.5 µg/ml.
    • Most Proteus spp. were highly susceptible, with over 85% inhibited by 0.10 µg/ml.
    • Piperacillin's activity was reduced with large inocula and varied with media composition and pH; it was more potent than carbenicillin and ticarcillin but less potent than PC-904 against gram-negative bacilli.

    Conclusions:

    • Piperacillin exhibits promising in vitro activity against key gram-negative pathogens.
    • Factors such as inoculum size, media, and pH influence piperacillin's effectiveness.
    • Piperacillin represents a valuable addition to the antibiotic armamentarium for treating infections caused by susceptible bacteria.