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Published on: June 29, 2009
Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description
Kerrie-Anne Chen1, Fabienne Brilot2, Russell C Dale2
1Department of Paediatric Neurology, Sydney Children's Hospital, Randwick, Australia.
Purpose:
To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE).
Results:
A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness.
Conclusion:
We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.
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