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Related Experiment Videos

Brain and peripheral opioid peptides after changes in ingestive behavior.

N H Majeed, W Lasoń, B Przewłocka

    Neuroendocrinology
    |January 1, 1986
    PubMed
    Summary

    Water and food deprivation, along with drug treatments, alter opioid peptide levels in rat brains, pituitaries, and guts. These changes in dynorphin, alpha-neoendorphin, and beta-endorphin suggest independent regulation tied to ingestive behavior.

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    Molecular neurobiology·2017

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Gastroenterology

    Background:

    • Opioid peptides like dynorphin (DYN), alpha-neoendorphin (alpha-NEO), and beta-endorphin (beta-E) play crucial roles in regulating physiological functions.
    • Understanding how ingestive behaviors and pharmacological interventions affect these peptides is vital for comprehending neuroendocrine and gastrointestinal regulation.

    Purpose of the Study:

    • To investigate the impact of water deprivation, food deprivation, and specific drug treatments (fenfluramine, muscimol) on the levels of ir-DYN, ir-alpha-NEO, and ir-beta-E.
    • To determine if these opioid peptide levels are affected differentially and independently in the brain, pituitary, and gut.

    Main Methods:

    • Measurement of immunoreactivity (ir) for DYN, alpha-NEO, and beta-E in rat brain (hypothalamus), pituitary (anterior and neurointermediate lobes), and duodenum.

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  • Subjecting rats to various conditions: water deprivation, food deprivation, chronic fenfluramine treatment, and acute muscimol treatment.

    • Main Results:

    • Water deprivation increased hypothalamic ir-DYN and ir-alpha-NEO, decreased pituitary neurointermediate lobe ir-DYN and ir-alpha-NEO, decreased hypothalamic and anterior pituitary ir-beta-E, and increased neurointermediate pituitary ir-beta-E.
    • Food deprivation and chronic fenfluramine increased hypothalamic ir-beta-E, while acute muscimol decreased it; these manipulations did not affect hypothalamic ir-DYN or ir-alpha-NEO.
    • Food deprivation significantly increased duodenal ir-DYN and ir-alpha-NEO, whereas chronic fenfluramine markedly decreased duodenal ir-DYN.

    Conclusions:

    • Ingestive behavior alterations and pharmacological interventions can differentially affect opioid peptide levels in the brain, pituitary, and gut.
    • The regulation of dynorphin, alpha-neoendorphin, and beta-endorphin appears to be independent across these distinct physiological systems.