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Updated: Aug 8, 2026

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Published on: August 19, 2008
Effects of amino acid neurotransmitter candidates on an identified insect motoneurone
Abstract:
The cell body of the fast coxal depressor motoneurone (Df) was used to examine the effects of a group of putative amino acid neurotransmitters. gamma-Aminobutyric acid (GABA) elicited a biphasic hyperpolarizing response, each component having a separate reversal potential. Both components were affected by the GABA antagonist picrotoxinin. L-Glutamate produced a hyperpolarizing response with a reversal potential of between -80 and -85 mV, and L-aspartate gave a similar but less potent effect. Kainic acid and quisqualic acid elicited depolarizing responses of up to 10 mV in amplitude. beta-Alanine and taurine produced a single hyperpolarization with a reversal potential similar to glutamate. Glycine was ineffective on motoneurone Df.
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