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Updated: Aug 26, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Effects of clorazepate dipotassium and placebo on psychomotor skills
Abstract:
24 normal, healthy subjects were assigned randomly to 15 mg clorazepate dipotassium or placebo groups in a double-blind study. Their performance on a psychological test battery was assessed 45 min. later. Clorazepate dipotassium produced statistically significant impairment in attention and simple reaction time compared with placebo. Performance on more complex tests of cognitive functioning showed no drug effects.
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