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Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media
10:45

Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media

Published on: June 14, 2013

Milk exosomes: beyond dietary microRNAs

Janos Zempleni1

  • 1Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE USA.

Genes & Nutrition
|July 12, 2017
PubMed

Insights

Dietary exosomes from bovine milk deliver microRNAs and other bioactive molecules to non-bovine species. Evidence supports the bioavailability of these microRNAs, prompting further research into how exosomes impact metabolism.

Area of Science:

  • Nutrition
  • Cell Biology
  • Biochemistry

Background:

  • Dietary exosomes, particularly from bovine milk, are recognized for their ability to transport various cargos to recipient cells across species.
  • A scientific debate exists regarding the bioavailability and bioactivity of microRNAs (miRNAs) delivered via these dietary exosomes.

Discussion:

  • This paper evaluates the existing evidence, concluding that the data supporting miRNA bioavailability within dietary exosomes is more substantial than the evidence challenging it.
  • The scientific community is urged to move beyond the microRNA controversy and explore broader mechanisms of exosome-mediated metabolic alteration.

Key Insights:

  • The bioavailability of microRNAs encapsulated in dietary exosomes is supported by compelling scientific evidence.
  • The functional impact of dietary exosomes extends beyond microRNAs, influencing host metabolism through diverse pathways.

Outlook:

  • Future research should focus on elucidating the novel mechanisms by which dietary exosomes modulate host metabolism.
  • Exploring other exosomal cargos and their interactions with recipient cells presents a promising avenue for nutritional and metabolic research.
Keywords:
ExosomesExtracellular vesiclesMilk

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