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Statin use and cognitive function in middle-aged adults with type 1 diabetes
Karen A Nunley1, Trevor J Orchard1, Christopher M Ryan1
1Karen A Nunley, Trevor J Orchard, Christopher M Ryan, Rachel Miller, Tina Costacou, Caterina Rosano, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, United States.
World Journal of Diabetes
|July 12, 2017
Summary
Statin use in adults with type 1 diabetes (T1D) was linked to increased odds of cognitive impairment, especially impacting memory. This association persisted even after accounting for other health factors.
Area of Science:
- Endocrinology and Metabolism
- Neuroscience
- Clinical Research
Background:
- Childhood-onset type 1 diabetes (T1D) can have long-term health implications.
- Cognitive function in T1D patients requires further investigation, particularly regarding medication effects.
Purpose of the Study:
- To investigate the association between statin use and cognitive impairment in middle-aged adults with a history of childhood-onset T1D.
Main Methods:
- 108 participants with childhood-onset T1D underwent neurocognitive assessments.
- Statin use history (never, 1-6 years, 7-12 years) was collected and analyzed.
- Logistic and linear regression models, including propensity score analysis, were used to assess cognitive outcomes.
Main Results:
- Statin use was associated with a significantly higher odds of cognitive impairment (up to nearly quintupled odds with 7-12 years of use).
- Worse performance in memory domains was observed in statin users compared to never users.
- Results remained consistent after adjusting for covariates and propensity score analysis, suggesting the association is not solely due to confounding by indication.
Conclusions:
- Statin use is associated with cognitive impairment, particularly memory deficits, in adults with childhood-onset T1D.
- These findings are notable as participants are at an age where age-related memory decline is not typically expected.
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