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Hypogonadotropic hypogonadism in men with hereditary hemochromatosis

Rabih El Osta1, Nicolas Grandpre2, Nicolas Monnin3

  • 1Urology Department of Brabois University Hospital, CHU Nancy, Vandœuvre-lès-Nancy, France.

Basic and Clinical Andrology
|July 12, 2017
PubMed

Insights

Hereditary hemochromatosis can silently cause hypogonadotropic hypogonadism (HH) in men, impacting fertility and sexuality. Early diagnosis and treatment are crucial for managing this iron overload disorder.

Area of Science:

  • Endocrinology
  • Genetics
  • Reproductive Medicine

Background:

  • Hereditary hemochromatosis is a genetic disorder characterized by excessive iron absorption.
  • It often progresses silently, leading to late diagnosis and complications.
  • Hypogonadotropic hypogonadism (HH) is a recognized complication affecting male reproductive health.

Purpose of the Study:

  • To review the impact of iron overload in hereditary hemochromatosis on male fertility.
  • To describe the manifestation of hypogonadotropic hypogonadism (HH) in affected males.
  • To explore potential treatment strategies for HH in the context of hemochromatosis.

Main Methods:

  • A comprehensive literature search was conducted on PubMed/Medline.
  • Search terms included 'Male infertility,' 'Hypogonadotropic Hypogonadism,' and 'Hereditary Hemochromatosis.'
  • Thirty-four relevant publications in English, French, and German up to September 2016 were included.

Main Results:

  • Iron overload from hereditary hemochromatosis can lead to hypogonadotropic hypogonadism (HH).
  • HH may manifest as decreased libido, erectile dysfunction, and impaired ejaculation.
  • Symptoms can significantly affect male sexuality and reproductive capacity.

Conclusions:

  • Hereditary hemochromatosis poses a risk for developing hypogonadotropic hypogonadism (HH) in males.
  • Earlier diagnosis of hemochromatosis may contribute to a decline in HH prevalence.
  • Understanding and addressing HH is vital for managing male reproductive health in hemochromatosis patients.

Keywords:
Hereditary HemochromatosisHypogonadotropic HypogonadismMale infertility

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