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Proximal flow to middle cerebral artery is associated with higher thrombus density in terminal internal carotid

Slaven Pikija1, Jozef Magdic2, Monika Killer-Oberpfalzer3

  • 1Department of Neurology Christian Doppler Medical Center Paracelsus Medical University Salzburg Austria.

Annals of Clinical and Translational Neurology
|July 12, 2017
PubMed

Insights

Proximal collaterals influence clot composition in acute ischemic stroke (AIS). Patients with MCA collaterals had denser clots and more leptomeningeal collaterals, suggesting collateral status impacts stroke evolution.

Area of Science:

  • Neuroscience
  • Radiology
  • Vascular Biology

Background:

  • Thrombus composition in acute ischemic stroke (AIS) is influenced by multiple factors.
  • Understanding these factors is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To investigate the role of proximal collaterals in determining thrombus characteristics in terminal internal carotid artery occlusion.
  • To explore the relationship between collateral status and clot density in AIS.

Main Methods:

  • Retrospective study of 39 AIS patients with internal carotid artery occlusion.
  • Assessed thrombus density on noncontrast CT and proximal collaterals on CT angiography.
  • Analyzed correlation between collateral status and clot characteristics.

Main Results:

  • Patients with proximal collaterals to the middle cerebral artery (MCA) showed significantly more hyperdense clots (P = 0.003).
  • A higher frequency of leptomeningeal collaterals was observed in patients with MCA collaterals (P = 0.008).

Conclusions:

  • Proximal collateral status is a significant determinant of thrombus composition in AIS.
  • These findings expand the understanding of factors influencing clot perviousness and stroke evolution.

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