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Related Concept Videos

The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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A Journey in Science: Cell-Cycle Control.

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  • 1The Francis Crick Institute, London, United Kingdom.

Molecular Medicine (Cambridge, Mass.)
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Summary
This summary is machine-generated.

This award preserves the history of scientific breakthroughs. It features personal accounts from researchers detailing their discoveries and their impact on medicine.

Keywords:
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Area of Science:

  • Cell biology
  • Translational medicine

Background:

  • The Anthony Cerami Award in Translational Medicine was established by *Molecular Medicine* to document historic scientific innovations.
  • The award recognizes seminal events and the investigators behind them, preserving the narratives of discovery.

Discussion:

  • Monographs feature original investigators recounting crucial early insights.
  • Essays capture the essence of scientific discovery and the birth of new research fields.

Key Insights:

  • These narratives highlight discoveries that influenced disease prevention, diagnosis, and treatment.
  • The award celebrates the impact of foundational research on modern medicine.

Outlook:

  • This volume features the monograph by Paul Nurse, a visionary in cell biology.
  • Dr. Nurse's story chronicles his scientific journey and contributions to the field.