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[Beta-mimetics and tachyphylaxis].

M Perrin-Fayolle

    Revue De Pneumologie Clinique
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Prolonged use of beta-mimetics may lead to tachyphylaxis, a reduced drug effectiveness, particularly in lymphocytes. While bronchial effects are unclear, corticosteroids and Ketotifen may offer protection against this desensitization.

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    Area of Science:

    • Pharmacology
    • Immunology

    Context:

    • Beta-mimetic medications are widely used for asthma management.
    • Prolonged use of these drugs can lead to tachyphylaxis, a form of drug tolerance.
    • Understanding the mechanisms and clinical implications of tachyphylaxis is crucial for optimizing asthma treatment.

    Purpose:

    • To review current knowledge on tachyphylaxis induced by prolonged beta-mimetic use in asthma.
    • To examine the organization of the adrenergic membrane system and desensitization mechanisms.
    • To evaluate experimental and clinical evidence of tachyphylaxis in asthmatic patients.

    Summary:

    • Studies on circulating cells like lymphocytes consistently demonstrate tachyphylaxis through decreased cyclic AMP and receptor density.
    • Evidence for tachyphylaxis in bronchial smooth muscle is contradictory, suggesting relative but not clinically significant desensitization.

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  • Therapeutic strategies, including corticosteroids and Ketotifen, may mitigate the risk of beta-mimetic tachyphylaxis.

    • Impact:

    • Highlights the need for further research into the clinical significance of bronchial tachyphylaxis.
    • Suggests potential protective roles for corticosteroids and Ketotifen in managing beta-mimetic tolerance.
    • Informs clinical practice regarding the long-term use of beta-mimetics in asthma patients.