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Overview of Admixture Mapping.

Daniel Shriner1

  • 1Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland.

Current Protocols in Human Genetics
|July 12, 2017
PubMed
Summary
This summary is machine-generated.

Admixture mapping identifies disease risks linked to ancestry. This method, particularly for diverse populations like those in the US, uses advanced techniques for accurate genetic analysis and improved disease gene discovery.

Keywords:
admixtureadmixture mappingancestry

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Area of Science:

  • Population genetics
  • Genomic medicine
  • Statistical genetics

Background:

  • Admixture mapping is crucial for identifying genetic variants associated with diseases exhibiting differential risk across ancestral groups.
  • Its application is prominent in admixed populations, such as those in the United States with Native American, European, and West African ancestry.

Purpose of the Study:

  • To outline the fundamental concepts of admixture mapping.
  • To describe various methods for inferring local ancestry and strategies for performing admixture mapping based on study design.
  • To compare and contrast admixture mapping with linkage and association analyses, emphasizing integration.

Main Methods:

  • Review of key admixture mapping concepts and principles.
  • Description of local ancestry inference approaches.
  • Explanation of admixture mapping strategies within linear mixed models.
  • Comparative analysis with linkage and association testing.

Main Results:

  • Admixture mapping provides a powerful framework for gene mapping in admixed populations.
  • Recent advancements have improved methods and reference data for ancestry inference.
  • Integration with association testing enhances the utility of admixture mapping.

Conclusions:

  • Admixture mapping is an effective tool for discovering genes influencing health disparities in admixed populations.
  • The method has evolved with improved statistical models and data resources.
  • Combining admixture mapping with association testing offers a comprehensive approach to genetic discovery.