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Updated: Feb 26, 2026

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Approach to the Synthesis of Briarane Diterpenes through a Dianionic Claisen Rearrangement and Ring-Closing
Michael T Crimmins1, Yan Zhang1, Philip S Williams1
1Kenan, Caudill, Venable, and Murray Laboratories of Chemistry University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Abstract:
The synthesis of the briarane-brianthein A core has been accomplished utilizing an extension of the dianionic Ireland-Claisen rearrangement to establish the C1 quaternary carbon and the adjacent C10 ring juncture stereocenters. Two sequential ring-closing metathesis reactions were exploited to construct the 6-10 trans fused ring system.
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