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Viral interactions with host cell Rab GTPases

Paul Spearman1

  • 1a Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.

Small Gtpases
|July 12, 2017
PubMed

Insights

Viruses hijack host cell transport systems, specifically Rab GTPases, to replicate. This review details how these viral interactions impact herpesviruses and HIV-1 late-stage replication.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses are obligate intracellular parasites.
  • Enveloped viruses depend on host cell vesicular trafficking for replication.
  • Rab GTPases are crucial for various cellular processes, including trafficking.

Purpose of the Study:

  • To review virus-Rab protein interactions.
  • To focus on Rab-related trafficking in herpesvirus and HIV-1 replication.

Main Methods:

  • Literature review of virus-Rab protein interactions.
  • Analysis of Rab GTPase roles in viral late-stage replication.

Main Results:

  • Rab GTPases are implicated in the replication of numerous human viral pathogens.
  • Rab-mediated trafficking pathways significantly influence herpesvirus and HIV-1 assembly and budding.

Conclusions:

  • Understanding virus-Rab interactions is key to deciphering viral replication strategies.
  • Targeting Rab pathways could offer novel antiviral therapeutic avenues for herpesviruses and HIV-1.
Keywords:
CMVHIV-1HSV-1RSVRab GTPasesviral glycoproteinvirus assembly

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