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Related Concept Videos

Rab Proteins01:14

Rab Proteins

5.3K
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
5.3K
Rab Cascades01:25

Rab Cascades

3.7K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.7K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

5.6K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.6K
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

4.6K
Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
4.6K
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

13.0K
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
13.0K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.7K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.7K

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Related Experiment Video

Updated: Feb 26, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

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Viral interactions with host cell Rab GTPases.

Paul Spearman1

  • 1a Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA.

Small Gtpases
|July 12, 2017
PubMed
Summary

Viruses hijack host cell transport systems, specifically Rab GTPases, to replicate. This review details how these viral interactions impact herpesviruses and HIV-1 late-stage replication.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses are obligate intracellular parasites.
  • Enveloped viruses depend on host cell vesicular trafficking for replication.
  • Rab GTPases are crucial for various cellular processes, including trafficking.

Purpose of the Study:

  • To review virus-Rab protein interactions.
  • To focus on Rab-related trafficking in herpesvirus and HIV-1 replication.

Main Methods:

  • Literature review of virus-Rab protein interactions.
  • Analysis of Rab GTPase roles in viral late-stage replication.

Main Results:

  • Rab GTPases are implicated in the replication of numerous human viral pathogens.
Keywords:
CMVHIV-1HSV-1RSVRab GTPasesviral glycoproteinvirus assembly

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Related Experiment Videos

Last Updated: Feb 26, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

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Viral Tracing of Genetically Defined Neural Circuitry
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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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  • Rab-mediated trafficking pathways significantly influence herpesvirus and HIV-1 assembly and budding.

    • Conclusions:

    • Understanding virus-Rab interactions is key to deciphering viral replication strategies.
    • Targeting Rab pathways could offer novel antiviral therapeutic avenues for herpesviruses and HIV-1.