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Impact of age at first childbirth on primary open-angle glaucoma

Sangshin Park1,2, Nam-Kyong Choi3,4

  • 1Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI.

Menopause (New York, N.Y.)
|July 12, 2017
PubMed

Insights

Having your first child at age 27 or later is linked to a lower risk of primary open-angle glaucoma (POAG) in postmenopausal women. This finding highlights the importance of childbirth timing for eye health.

Area of Science:

  • Ophthalmology
  • Reproductive Health
  • Epidemiology

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
  • The relationship between reproductive factors, such as age at first childbirth, and POAG risk remains understudied.
  • Understanding these associations can inform public health strategies and patient counseling.

Purpose of the Study:

  • To investigate the association between the age at first childbirth and the prevalence of POAG in postmenopausal women.
  • To examine the mediating role of parity in the relationship between age at first childbirth and POAG.

Main Methods:

  • Cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (2010-2012).
  • Inclusion of postmenopausal women aged 50 years and above.
  • Logistic regression and mediation analyses were employed, accounting for complex survey sampling.

Main Results:

  • The study included 4,057 postmenopausal women with a mean age at first childbirth of 23.7 years; 3.4% had POAG.
  • POAG prevalence was lowest (1.8%) among women with first childbirth between ages 27-44 years.
  • Late first delivery (≥27 years) was associated with a significantly reduced risk of POAG (OR, 0.25; 95% CI, 0.10-0.65) compared to early delivery (13-20 years).

Conclusions:

  • First childbirth at age 27 years or older is associated with a decreased risk of POAG in postmenopausal women.
  • Reduced parity, resulting from later first childbirth, partially explains the attenuated relationship between age at first childbirth and POAG risk.
Abstract

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