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A prototype PET/SPECT/X-rays scanner dedicated for whole body small animal studies.

Maritina Rouchota1, Maria Georgiou, Eleftherios Fysikopoulos

  • 1University of Patras, Rion, Patras, Greece. m.rouchota@upatras.gr.

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We developed a novel tri-modal imaging system combining single photon emission computed tomography (SPET), positron emission tomography (PET), and computed tomography (CT) for whole-body mouse imaging. This cost-effective system offers efficient anatomical and functional imaging capabilities.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Nuclear Medicine

Background:

  • Advanced imaging systems are crucial for preclinical research.
  • Integrating multiple imaging modalities offers comprehensive data.
  • Existing systems can be costly and complex.

Purpose of the Study:

  • To present a prototype tri-modal imaging system (SPET-PET-CT).
  • To evaluate its performance in planar mode for whole-body mouse imaging.
  • To provide a cost-effective and scalable imaging platform.

Main Methods:

  • The system integrates SPET, PET, and CT subsystems on a rotating gantry.
  • SPET uses Position Sensitive Photomultiplier Tubes (PSPMT) with NaI(Tl) scintillators.
  • PET utilizes PSPMT with BGO scintillators, and CT employs a micro focus X-ray tube with a CMOS detector.

Main Results:

  • SPET achieved a spatial resolution of 1.88mm (FWHM) and sensitivity of 107.5cpm/0.037MBq.
  • PET demonstrated an average spatial resolution of 3.5mm (FWHM) and peak sensitivity of 29.9cpm/0.037MBq.
  • CT offered a spatial resolution of 3.5lp/mm with contrast discrimination below 2%.

Conclusions:

  • A compact tri-modal SPET-PET-CT system was successfully developed and evaluated for planar imaging.
  • The system provides efficient, accurate anatomical and functional imaging with semi-quantitative results.
  • This open, scalable platform offers comparable performance to existing systems at lower cost and complexity.