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Updated: Feb 26, 2026
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma
Mira Sibai1, Carl Fisher1, Israel Veilleux2
1University of Toronto, Department of Medical Biophysics, Faculty of Medicine, Ontario, CanadabUniversity Health Network, Princess Margaret Cancer Center, Ontario, Canada.
Abstract:
5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for
