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Related Experiment Video

Updated: Feb 26, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.

Masatoshi Fujita¹, Tadasu Sato, Takehiro Yajima

¹Division of Dento-Oral Anesthesiology, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Cells, Tissues, Organs

|July 12, 2017

Summary

This summary is machine-generated.

Transient Receptor Potential Cation channel subfamily C (TRPC) channels are found in rat oral and craniofacial sensory, autonomic, and motor neurons. These TRPC channels are likely involved in nerve function within these head and neck structures.

Keywords:

Immunohistochemistry Motor endplate Olfactory cell Rat model TRPC Taste bud Trigeminal ganglion

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Published on: April 1, 2022

Area of Science:

Neuroscience
Molecular Biology
Physiology

Background:

Transient Receptor Potential Cation channel subfamily C (TRPC) channels are nonselective monovalent cation channels regulating calcium (Ca2+) influx.
Understanding the distribution of TRPC channels in craniofacial structures is crucial for elucidating their physiological roles.

Purpose of the Study:

To investigate the expression and distribution of TRPC1, TRPC3, and TRPC4 in rat oral and craniofacial peripheral structures.
To determine the potential involvement of TRPC channels in sensory, autonomic, and motor functions in the head and neck region.

Main Methods:

Immunohistochemistry was employed to detect TRPC1, TRPC3, and TRPC4 expression in various rat craniofacial tissues.
Double immunofluorescence was used to examine co-localization of TRPC channels with specific neuronal markers like calcitonin gene-related peptide.

Main Results:

TRPC1, TRPC3, and TRPC4 were found in a significant percentage of sensory neurons in the trigeminal ganglion (TG).
Co-expression of TRPCs with calcitonin gene-related peptide was observed in small to medium-sized TG neurons.
TRPC1 and TRPC3 were present in all sympathetic neurons of the superior cervical ganglion.
TRPC1, TRPC3, and TRPC4 immunoreactivity was detected in parasympathetic neurons, gustatory cells, olfactory cells, and motor endplates.

Conclusions:

TRPC channels are widely distributed across sensory, autonomic, and motor pathways in the oral and craniofacial peripheries.
The presence of TRPCs in these diverse neuronal populations suggests their significant role in craniofacial sensory perception, autonomic regulation, and motor control.