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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Feb 26, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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[Treatment Strategy for Soft Tissue Sarcomas].

Akihiko Matsumine1

  • 1Dept. of Orthopaedics and Rehabilitation Medicine, Unit of Surgery, Division of Medicine, Faculty of Medical Sciences, University of Fukui.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 13, 2017
PubMed
Summary

Surgical excision is the primary treatment for localized soft tissue sarcoma. Adjuvant therapies like chemotherapy and radiation, or combinations for advanced cases, can improve patient outcomes and quality of life.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Soft tissue sarcomas are malignant tumors requiring tailored treatment strategies.
  • Treatment decisions depend on tumor characteristics like type, grade, size, and location.

Purpose of the Study:

  • To outline current therapeutic approaches for soft tissue sarcoma.
  • To emphasize the role of surgery, chemotherapy, and radiation in managing localized, unresectable, and advanced disease.

Main Methods:

  • Review of established treatment modalities for soft tissue sarcoma.
  • Discussion of surgical excision as the primary intervention for localized tumors.
  • Consideration of adjuvant therapies including chemotherapy and radiation therapy (including particle beam).

Main Results:

  • Surgical excision is the most effective treatment for localized soft tissue sarcoma.
  • Adjuvant chemotherapy and/or radiation therapy are recommended based on specific tumor factors.
  • Radiation therapy, including particle beam, is an option for unresectable tumors.
  • Combination therapy (surgery, chemotherapy, radiation) may improve prognosis and quality of life (QOL) in recurrent or metastatic cases.

Conclusions:

  • Multimodal treatment approaches are essential for optimizing soft tissue sarcoma management.
  • Therapeutic strategies must be individualized based on disease extent and patient factors.
  • Combination therapies offer potential benefits for patients with advanced or recurrent disease.