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A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
A Acun1, D C Vural2, P Zorlutuna3,4
1Bioengineering Graduate Program, University of Notre Dame, Notre Dame, IN, 46556, USA.
Scientific Reports
|July 13, 2017
Summary
Aging is a complex biological process. This study reveals that while cellular damage drives aging, cell interactions significantly influence tissue death and systemic aging consequences.
Area of Science:
- Gerontology
- Tissue Engineering
- Systems Biology
Background:
- Aging is a fundamental biological problem with many cellular theories but limited understanding of macroscopic consequences.
- The cascade from microscopic cellular failures to tissue, organ, and organismal aging is poorly understood.
Purpose of the Study:
- To bridge the gap between microscopic cell failure and macroscopic aging manifestations.
- To investigate the role of cellular interdependence and interactions in aging tissues.
Main Methods:
- Utilized tissue-engineered constructs to control cellular damage and cell-cell distances.
- Established experimental models to observe aging processes at the tissue level.
Main Results:
- Microscopic mechanisms were confirmed as drivers of aging.
- Cell-cell interdependency was identified as a critical factor in tissue death during aging.
- Evidence was provided linking cellular aging to higher systemic consequences.
Conclusions:
- Cellular aging mechanisms are influenced by the complex interactions between cells.
- Intercellular dynamics are crucial for understanding tissue aging and its systemic effects.
- This research provides a framework for connecting cellular aging to organismal health outcomes.
