Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Propranolol monotherapy versus propranolol plus prednisone for diffuse infantile hepatic haemangioma: a randomized clinical trial.

World journal of pediatrics : WJP·2026

Same author

Application Value of Radiomics-Based Machine Learning for Preoperative Risk Stratification of Bladder Cancer: Systematic Review and Meta-Analysis.

Journal of medical Internet research·2026

Same author

Effect of the modified RADAR, No-touch, and conventional techniques on arteriovenous fistula outcomes.

Renal failure·2026

Same author

m<sup>6</sup>A Modification Genetic Variants Associated with Autism Spectrum Disorder Risks.

Molecular neurobiology·2026

Same author

Training in Gabor Orientation Identification Optimizes the Temporal Window of Adults With Anisometropic Amblyopia.

Investigative ophthalmology & visual science·2026

Same author

Transcranial Magnetic Stimulation Combined with Nursing Intervention in Children with Autism Spectrum Disorder and Its Effects on Developmental Quotient and Serum Neurotransmitters.

Journal of multidisciplinary healthcare·2026

Search research articles

Related Experiment Video

Updated: Feb 26, 2026

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Published on: September 28, 2022

Efficient Characterization and Classification of Contrast Sensitivity Functions in Aging.

Fang-Fang Yan^1,2, Fang Hou³, Zhong-Lin Lu³

¹CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.

Scientific Reports

|July 13, 2017

Summary

A new quick method accurately measures contrast sensitivity function (CSF) in older adults, showing significant age-related vision decline. This tool is reliable for research and clinical use.

More Related Videos

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects

Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects

Published on: May 10, 2019

Related Experiment Videos

Last Updated: Feb 26, 2026

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Published on: September 28, 2022

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Author Spotlight: Understanding Age-Related Macular Degeneration Pathophysiology with QAF Workflow

Published on: May 26, 2023

Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects

Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects

Published on: May 10, 2019

Area of Science:

Vision science
Gerontology
Ophthalmology

Background:

Contrast sensitivity function (CSF) comprehensively characterizes spatial vision.
Accurate CSF measurement is crucial for understanding aging vision.
Existing methods may not be rapid or effective for the aging population.

Purpose of the Study:

To validate the quick CSF method for assessing spatial vision in the aging population.
To determine the reliability and effectiveness of the quick CSF method.
To evaluate age-related differences in contrast sensitivity.

Main Methods:

Employed a novel quick CSF method utilizing Bayesian adaptive inference and information gain.
Estimated four key parameters defining an individual's CSF.
Recruited young and older adult observers, screened for ocular and mental health.

Main Results:

Quick CSF method results closely aligned with the traditional Ψ method.
Demonstrated excellent test-retest reliability for the quick CSF method.
Accurately identified significant differences in CSF between young and old groups, confirming age-related decline.

Conclusions:

The quick CSF method is a valid, rapid, and reliable tool for measuring contrast sensitivity in older adults.
Aging significantly impairs contrast sensitivity.
The quick CSF method shows strong potential for laboratory research and clinical applications in gerontology.