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Differences in Mean Platelet Volume and Platelet Count between Children with Simple and Complex Febrile Seizures
Ali Nikkhah1, Mohammad Reza Salehiomran2, Seyedeh Samane Asefi3
1Pediatric Neurology Department, Mazandaran University of Medical Sciences, Sari, Iran.
Insights
This study found no significant difference in Mean Platelet Volume (MPV) or platelet counts between simple and complex febrile seizures in children. Further research is needed to explore these inflammation markers.
Area of Science:
- Pediatrics
- Neurology
- Hematology
Background:
- Febrile seizures are common in childhood.
- Inflammation plays a role in febrile seizures.
- Mean Platelet Volume (MPV) and platelet count are potential inflammatory markers.
Purpose of the Study:
- To investigate the relationship between MPV and platelet counts in simple febrile seizures (SFS) versus complex febrile seizures (CFS).
- To evaluate MPV and platelet counts as inflammation markers in SFS and CFS.
Main Methods:
- Retrospective comparative study of 356 children aged 5 months to 6 years.
- Inclusion criteria: diagnosis of SFS or CFS.
- Data collected between March 2011 and December 2015.
Main Results:
- No statistically significant difference in MPV between CFS (8.32±0.48fl) and SFS (8.58±0.34fl) groups.
- No statistically significant difference in platelet counts between CFS (315.03×10³ ±117.17×10³) and SFS (291.82×10³ ±87.49×10³) groups.
- Mean age was similar across both groups.
Conclusions:
- No significant differences were observed in MPV or platelet counts between children with SFS and CFS.
- Further studies are recommended to explore the role of these markers in febrile seizures.
Objective:
The aim of our study was to find the relationship of MPV (Mean Platelet Volume) levels and platelet counts as markers of inflammation between simple and complex febrile seizures.
Materials & Methods:
In this retrospective comparative study, we investigated the recordings of 356 children between 5 months and 6 yr with diagnosis of simple and complex febrile seizure (SFS&CFS) in Amircola's Children's Hospital, Babol University of Medical Sciences, Babol, Iran between Mar 2011 and Dec 2015.
Results:
Mean age was similar in two groups. The MPV of the CFS group (8.32±0.48fl) was lower than that of the SFS group (8.58±0.34fl) but this difference was not significant statistically. The platelet count of the CFS group (315.03×103 ±117.17×103) was higher than that of SFS group (291.82×103 ± 87.49×103) but there was no significant statistical difference.
Conclusion:
We did not find significant differences between two groups. Therefore, further studies about this idea should be performed.
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