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Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

651
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
491
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

667
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
667
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

565
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
565
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

700
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
700
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

385
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
385

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Position paper ANMCO in collaboration with Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P): 'the management of hospital discharge'.

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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Microvascular dysfunction in infiltrative cardiomyopathies.

Ornella Rimoldi1, Francesco Maranta2

  • 1CNR Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Via Fratelli Cervi, 93, 20090, Segrate, Italy. rimoldi.ornella@hsr.it.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 13, 2017
PubMed
Summary
This summary is machine-generated.

Infiltrative heart diseases cause heart failure by altering heart muscle and blood vessels. Non-invasive imaging like PET and MRI can measure these changes.

Keywords:
Coronary artery diseasecardiomyopathycoronary blood flowvasodilator stress

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Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Pathophysiology

Background:

  • Infiltrative heart diseases involve myocardial tissue changes, leading to mechanical dysfunction and congestive heart failure.
  • Coronary microvasculature remodeling and dysfunction are key features of these conditions.
  • Impaired vasodilatory function and mechanical crosstalk imbalance contribute to disease progression.

Purpose of the Study:

  • To investigate the non-invasive measurement of mechanical and vascular dysfunction in infiltrative heart diseases.
  • To correlate imaging findings with the pathophysiology of congestive heart failure in these conditions.

Main Methods:

  • Utilizing advanced non-invasive imaging techniques.
  • Employing Positron Emission Tomography (PET) for functional assessment.
  • Utilizing Cardiac Magnetic Resonance (CMR) for structural and mechanical evaluation.

Main Results:

  • Demonstrated ability to quantify myocardial mechanical dysfunction non-invasively.
  • Showcased measurement of coronary microvasculature remodeling and impaired vasodilatory capacity.
  • Established correlation between imaging biomarkers and clinical manifestations of heart failure.

Conclusions:

  • Non-invasive imaging, including PET and CMR, is effective in assessing the complex cardiovascular alterations in infiltrative heart diseases.
  • These techniques provide valuable insights into the mechanisms of heart failure development in these conditions.
  • Quantitative imaging can aid in diagnosis, monitoring, and understanding treatment responses.