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Updated: Feb 26, 2026

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Microvascular dysfunction in infiltrative cardiomyopathies

Ornella Rimoldi1, Francesco Maranta2

  • 1CNR Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Via Fratelli Cervi, 93, 20090, Segrate, Italy. rimoldi.ornella@hsr.it.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 13, 2017
PubMed

Insights

Infiltrative heart diseases cause heart failure by altering heart muscle and blood vessels. Non-invasive imaging like PET and MRI can measure these changes.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Pathophysiology

Background:

  • Infiltrative heart diseases involve myocardial tissue changes, leading to mechanical dysfunction and congestive heart failure.
  • Coronary microvasculature remodeling and dysfunction are key features of these conditions.
  • Impaired vasodilatory function and mechanical crosstalk imbalance contribute to disease progression.

Purpose of the Study:

  • To investigate the non-invasive measurement of mechanical and vascular dysfunction in infiltrative heart diseases.
  • To correlate imaging findings with the pathophysiology of congestive heart failure in these conditions.

Main Methods:

  • Utilizing advanced non-invasive imaging techniques.
  • Employing Positron Emission Tomography (PET) for functional assessment.
  • Utilizing Cardiac Magnetic Resonance (CMR) for structural and mechanical evaluation.

Main Results:

  • Demonstrated ability to quantify myocardial mechanical dysfunction non-invasively.
  • Showcased measurement of coronary microvasculature remodeling and impaired vasodilatory capacity.
  • Established correlation between imaging biomarkers and clinical manifestations of heart failure.

Conclusions:

  • Non-invasive imaging, including PET and CMR, is effective in assessing the complex cardiovascular alterations in infiltrative heart diseases.
  • These techniques provide valuable insights into the mechanisms of heart failure development in these conditions.
  • Quantitative imaging can aid in diagnosis, monitoring, and understanding treatment responses.

Keywords:
Coronary artery diseasecardiomyopathycoronary blood flowvasodilator stress

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