Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes.

medRxiv : the preprint server for health sciences·2026
Same author

Multimodal blood based proteomic profiling reveals insights into mechanisms of immunotherapy resistance.

Nature communications·2026
Same author

Face-name associative memory in temporal lobe epilepsy: Region-specific insights in right-hemisphere onset.

Epilepsy research·2026
Same author

Hemispherectomy in infants: an institutional experience with 21 patients.

Journal of neurosurgery. Pediatrics·2026
Same author

HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.

Communications biology·2026
Same author

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 26, 2026

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
09:10

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

Published on: November 15, 2024

992

Laser Interstitial Thermal Therapy for Epilepsy.

Eric Prince1, Shahin Hakimian1, Andrew L Ko2

  • 1Departments of Neurology and Neurological Surgery, University of Washington, Box 359745, 325 Ninth Ave, Seattle, WA, 98104, USA.

Current Neurology and Neuroscience Reports
|July 13, 2017
PubMed
Summary

MRI-guided laser interstitial thermal therapy (MgLiTT) offers a minimally invasive option for epilepsy treatment. This precise technique effectively ablates deeper brain targets with reduced risks and shorter recovery times.

Keywords:
AmygdalohippocampectomyDrug-resistant epilepsyEpilepsyEpilepsy surgeryLaser interstitial thermal therapy

More Related Videos

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.6K
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.5K

Related Experiment Videos

Last Updated: Feb 26, 2026

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
09:10

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

Published on: November 15, 2024

992
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.6K
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.5K

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Technology

Background:

  • MRI-guided laser interstitial thermal therapy (MgLiTT) is an FDA-approved technique for soft tissue ablation.
  • It utilizes a narrow cannula for stereotactic targeting and heating of deep cerebral structures.
  • Real-time temperature monitoring ensures precise lesion creation and minimizes damage to surrounding brain tissue.

Purpose of the Study:

  • To evaluate the application and efficacy of MgLiTT in the surgical treatment of epilepsy.
  • To assess its suitability for targeting deeper brain structures like the hippocampus and amygdala.
  • To explore its potential benefits for mesial temporal epilepsy, particularly with unilateral hippocampal sclerosis.

Main Methods:

  • Stereotactic targeting of deeper cerebral structures using a narrow cannula.
  • Real-time monitoring of localized tissue temperature changes during thermal ablation.
  • Application of MgLiTT for epilepsy treatment, focusing on deeper or discrete lesions.

Main Results:

  • MgLiTT produces precise and reliable lesions in the brain.
  • The technique minimizes injury to surrounding brain tissue, potentially reducing risks to neurological function.
  • It involves a burr hole approach, leading to less operative risk, discomfort, and shorter hospitalizations.

Conclusions:

  • MgLiTT is increasingly applied to epilepsy surgery, especially for seizures originating from deeper structures.
  • It shows emerging effectiveness for eliminating seizures in mesial temporal epilepsy with unilateral hippocampal sclerosis.
  • MgLiTT may offer a lower risk of cognitive deficits compared to anterior temporal lobectomy.