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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Long Noncoding RNAs and Cardiac Disease.

Simona Greco1, Antonio Salgado Somoza2, Yvan Devaux2

  • 11 Molecular Cardiology Laboratory, IRCCS Policlinico San Donato , Milan, Italy .

Antioxidants & Redox Signaling
|July 13, 2017
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial regulators of gene expression in the heart. Further research into lncRNAs will unlock their potential as cardiovascular disease biomarkers and therapeutic targets.

Keywords:
biomarkersgene expressionheart diseaseslong noncoding RNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Science

Background:

  • Gene expression regulation is vital for maintaining homeostasis.
  • Long noncoding RNAs (lncRNAs) are key regulators across epigenetic, transcriptional, and post-transcriptional levels.
  • lncRNAs are implicated in various biological processes, including cardiac function and disease.

Purpose of the Study:

  • To review the role of lncRNAs in cardiac homeostasis and disease.
  • To discuss methodologies for studying cardiac lncRNAs.
  • To explore the potential of lncRNAs as therapeutic targets and biomarkers for cardiovascular diseases (CVD).

Main Methods:

  • Literature review and synthesis of current research on lncRNAs in the cardiovascular system.
  • Discussion of challenges in lncRNA research, such as low sequence conservation.
  • Exploration of emerging concepts and approaches for lncRNA investigation.

Main Results:

  • lncRNAs play significant roles in regulating heart function and are implicated in CVD progression.
  • The presence of lncRNAs in the blood suggests their potential as accessible biomarkers.
  • Understanding lncRNA mechanisms is essential for advancing CVD treatment strategies.

Conclusions:

  • Further investigation into lncRNA regulation and function in the heart is critical.
  • lncRNAs hold promise as future therapeutic targets and diagnostic biomarkers for cardiovascular diseases.
  • Enhanced knowledge of lncRNAs can lead to more effective CVD treatments.