Related Experiment Video
Updated: Feb 26, 2026

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
Lightweight predicate extraction for patient-level cancer information and ontology development
Muhammad Amith1, Hsing-Yi Song1, Yaoyun Zhang1
1School of Biomedical Informatics, University of Texas Health Science Center, Fannin Street, Houston, USA.
Open Information Extraction (OIE) simplifies ontology development for public health by extracting knowledge triples from patient-centric sources. This automated approach achieves 80-89% precision, making ontology creation more accessible.
Area of Science:
- Biomedical Informatics
- Natural Language Processing
- Knowledge Engineering
Background:
- Ontology development is resource-intensive, posing challenges for novices.
- Automated natural language processing tools can aid ontology creation.
- Focus on public health ontologies using patient-centric MedlinePlus data for HPV-related cancers.
Purpose of the Study:
- Demonstrate the utility of lightweight Open Information Extraction (OIE) for ontology seeding.
- Develop a custom application to facilitate knowledge triple extraction.
- Enable novices to contribute to public health knowledgebase development.
Main Methods:
- Utilized a lightweight Open Information Extraction (OIE) tool.
- Developed a custom application interfacing with an information extraction library.
- Extracted knowledge triples from patient-centric MedlinePlus sources on HPV-causing cancers.
Main Results:
- Achieved 80-89% precision in knowledge triple extraction.
- Generated accurate triples suitable for OWL/RDF conversion.
- Demonstrated the feasibility of automated ontology seeding.
Conclusions:
- Open Information Extraction (OIE) provides an effective and accessible method for ontology development.
- Automated extraction significantly reduces the resource and time investment.
- Facilitates the creation of public health knowledgebases.
Related Concept Videos
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Survival Analysis
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...

