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Published on: July 12, 2024
Survival and Recovery in Severely Wasted Under-five Children Without Community Management of Acute Malnutrition
Harshpal Singh Sachdev1, Sikha Sinha, Neha Sareen
1Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research; and Departments of *Gastroenterology and Human Nutrition, and #Biostatistics, All India Institute of Medical Sciences; New Delhi, India. Correspondence to: Dr Harshpal Singh Sachdev, Senior Consultant, Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India. hpssachdev@gmail.com.
Insights
Severely wasted children in rural India showed low case-fatality rates (1.2%-2.7%) without malnutrition programs. Approximately 25-30% experienced spontaneous recovery over time, highlighting the need for targeted interventions.
Area of Science:
- Public Health
- Pediatrics
- Nutrition Science
Background:
- Acute malnutrition remains a significant global health challenge, particularly in low-resource settings.
- Effective management strategies are crucial for improving child survival and long-term health outcomes.
Purpose of the Study:
- To assess the survival and recovery rates of severely wasted children in the absence of a community management program.
- To identify factors influencing mortality and recovery in this vulnerable population.
Main Methods:
- A cohort of 409 severely wasted children (aged 6-59 months) was identified through a community survey in rural India.
- Follow-up data on survival and recovery (defined as weight-for-height Z-score ≥-2) were collected.
- Statistical analysis identified predictors of mortality and recovery.
Main Results:
- The case-fatality rate ranged from 1.2% to 2.4% within six months of enrollment.
- Younger age, poorer household head occupation, and lower anthropometric measurements at enrollment predicted higher mortality.
- Spontaneous recovery was observed in approximately 31% of survivors, with 30% remaining severely wasted and 39% moderately wasted at follow-up.
Conclusions:
- Severely wasted children in this setting exhibited a low case-fatality rate without formal management programs.
- Long-term spontaneous recovery occurred in about 25-30% of cases.
- Interventions targeting younger children and those with poorer socioeconomic indicators may be beneficial.
Objective:
To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme.
Design:
Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 2013).
Setting:
Rural Meerut District, Uttar Pradesh, India.
Participants:
409 severely wasted (WHO weight-for-height <-3Z), 6- to 59-month-old children.
Outcome Measures:
Survival and recovery (weight-for-height ≥-2Z).
Results:
Median (IQR) follow-up contact duration was 7.4 (6.6, 10.1) months. Among 11 deaths, there were 5 (case-fatality 1.2%), 6 (1.5%), 8 (2.0%) and 10 (2.4%) events within 1, 1.5, 4 and 6 months of enrolment, respectively. Ten deaths occurred in children aged between 6 and 24 months. Younger age (P=0.04), poorer household-head occupation (P=0.04) and lower enrolment anthropometry (any variable; P<0.001) were significant predictors of mortality. Children below 18 months of age had higher adjusted mortality risk (HR 4.7; 95% CI 0.95, 22.51; P=0.053). At follow-up, 30% of survivors were still severely wasted, 39% were moderately wasted (weight-for-height -3 to <-2Z) and 31% had recovered spontaneously. Younger age (P<0.001), female gender (P=0.04) and longer follow-up duration (P=0.003) were significant independent predictors of recovery. The adjusted OR (95% CI) for recovery <24 months was 2.81 (1.70, 4.65).
Conclusion:
Without community management of acute malnutrition in rural Meerut District, severely wasted children had low (1.2%-2.7%) case-fatality with long-term spontaneous recovery of around 25-30%.
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