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Relationship Between Immune Parameters and Non-alcoholic Fatty Liver Disease in Obese Children

Jun-Qi Shi1, Wen-Xia Shen, Xiang-Zhi Wang

  • 1Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine; Zhejiang Province; China. Correspondence to: Dr Chao-Chun Zou, Children's Hospital, Zhejiang University School of Medicine, Binsheng Road, Hangzhou 310051, Zhejiang Province, China. zcc14@zju.edu.cn.

Indian Pediatrics
|July 13, 2017
PubMed

Insights

Obese children with non-alcoholic fatty liver disease (NAFLD) show signs of chronic inflammation. While obesity, high LDL-C, and insulin resistance are risk factors, interleukin-10 may offer protection against NAFLD.

Area of Science:

  • Pediatric Endocrinology
  • Hepatology
  • Immunology

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a growing concern in obese children.
  • Obesity is linked to metabolic dysfunction and chronic inflammation.
  • Understanding the immune parameters associated with NAFLD in pediatric obesity is crucial for early intervention.

Purpose of the Study:

  • To investigate the relationship between immune parameters and NAFLD in obese children.
  • To identify risk factors and potential protective factors for NAFLD in this population.

Main Methods:

  • A cross-sectional, hospital-based study conducted in Zhejiang Province, China.
  • 117 obese children and 209 healthy non-obese children were compared.
  • Immune parameters, glucose metabolism, and lipid metabolism were assessed, with obese children categorized by NAFLD severity.

Main Results:

  • Obese children exhibited significantly higher body mass index (BMI), insulin resistance (HOMA-IR), dyslipidemia, and elevated levels of white blood cells, neutrophils, and interleukin-6 (IL-6) compared to controls.
  • Interleukin-10 (IL-10) levels were higher in obese children with severe NAFLD (steatohepatitis).
  • Logistic regression identified BMI, LDL-C, HOMA-IR, and IL-10 as independent factors associated with NAFLD.

Conclusions:

  • Obese children with NAFLD demonstrate evidence of low-grade chronic inflammation.
  • Obesity, dyslipidemia, and insulin resistance are confirmed risk factors for pediatric NAFLD.
  • Interleukin-10 (IL-10) may play a protective role in the development of NAFLD in obese children.
Abstract

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