Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds

Paolo Luciano1, Concetta Imperatore1, Maria Senese1

  • 1Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II" , Via D. Montesano, 49, I-80131 Napoli, Italy.

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Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
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