Related Experiment Video
Updated: Feb 26, 2026

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
Published on: October 3, 2014
Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds
Paolo Luciano1, Concetta Imperatore1, Maria Senese1
1Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II" , Via D. Montesano, 49, I-80131 Napoli, Italy.
Abstract:
The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
Related Concept Videos
Phosphodiester Linkages
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
The Phosphorus Cycle

