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Updated: Feb 26, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Neurological manifestations of dengue in Central Brazil
Marianna Peres Tassara1,2, Adriana Oliveira Guilarde1,2, Benigno Alberto Moraes da Rocha1
1Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Introduction::
The incidence of dengue has increased throughout the 2000s with a consequent global increase in atypical clinical forms.
Methods::
This study reports a series of cases of neurological dengue out of 498 confirmed cases of laboratory dengue in Goiânia, Brazil. Cases were confirmed based on viral RNA detection via polymerase chain reaction or IgM antibody capture.
Results::
Neurological symptoms occurred in 5.6% of cases, including paresthesia (3.8%), encephalitis (2%), encephalopathy (1%), seizure (0.8%), meningoencephalitis (0.4%), and paresis (0.4%). DENV-3 was the predominant circulating serotype (93%).
Conclusions::
We reported dengue cases with neurological manifestations in endemic area.
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